Mucosal SIV Vaccines with Bacterial Adjuvants Prevent SIV Infection in Macaques


A new paradigm of mucosal vaccination against HIV infection has been investigated in the macaque model. A vaccine consisting of inactivated SIVmac239 particles together with a living bacterial adjuvant (either the Calmette & Guerin bacillus, lactobacillus plantarum or Lactobacillus rhamnosus) was administered to macaques via the vaginal or oral/intragastic route. In contrast to all established human and veterinary vaccines, these three vaccine regimens did not elicit SIV-specific antibodies nor cytotoxic T-lymphocytes but induced a previously unrecognized population of non-cytolytic MHCIb/E-restricted CD8+T regulatory cells that suppressed the activation of SIV positive CD4+ T-lymphocytes. SIV reverse transcription was thereby blocked in inactivated CD4+ T-cells; the initial burst of virus replication was prevented and the vaccinated macaques were protected from a challenge infection. Three to 14 months after intragastric immunization, 24 macaques were challenged intrarectally with a high dose of SIVmac239 or with the heterologous strain SIV B670 (both strains grown on macaques…

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One of the biblical foundations of marriage is mutual submission[ Proverbs 31 man]


Eph 5:21 “Submit to one another out of reverence for Christ”

The Key word is to one another, not one partner to the other. Both Man and wife are called to do this (submission) to each other. The rest of the text is just further clarifies the type of submission that each partner in the marriage has to do.

I was very curious about the role of the man in this and what is expected of him. This is due to the fact that

  1. 1.       The bible in Ephesians seems to be saying it is his privilege to give himself to his wife as a loving sacrific.
  2. 2.       The standard is what God has done for the church is what man must do for his wife

So I got to read about the type of man that the Proverbs 31 woman deserves, because every man prays and wants to have such a woman as a wife. [Wife in the same of an equal partner not subordinate] and I found 5 attributes that I hope men [both husbands and those to be] will look at carefully and see if they do deserve the proverbs 31 Woman.

Here goes:

1. A Man of Noble Character (v. 10)

The Proverbs 31 man lives a life of noble character. Think about it, a Proverbs 31 woman (“virtuous wife”) deserves a husband of noble character, a man of virtue. Do you have a Noble character?

[Keep in mind that I am not talking about possessions here, no C’s whatever number they are starting for 3 onwards. I can’t keep up really]

2. A Man Who Trusts His Wife (v. 11)

The Proverbs 31 man trusts his wife and lives a life his wife can trust. I know that some men don’t even disclose how much they earn [salary] to their wives for whatever reason. Trust builds goodwill; goodwill leads to closeness. Where there is trust, there is peace.

3. A Man Who Leads (v. 23)

The Proverbs 31 man is “respected” at the city gate. That means he is looked to as a leader in the community. Even more than being a leader in the public forum, a man must lead his wife and children at home. It’s the biblical model of servant-leadership (Ephesians 5:25) for the family. There is no mention of dictatorial tendencies, no cohesion no threats like “or else”.

4. A Man of Wisdom (v. 23)

The Proverbs 31 man in v. 23 took “his seat among the elders” [Young but wise]. He is a man of wisdom. A man who is looked to for counsel, and he is a sounding board for those seeking input and advice. We often think that one must be older to be an elder. That’s not necessarily always the case. A young man whose seeks Godly wisdom can develop a reputation for consistent, well-thought out decision making. Being considered an elder is an earned position, not simply based on one’s age.

5. A Man of Blessing (v. 28)

The Proverbs 31 man recognizes the contributions of his wife and appreciates her for who she is and all that she does. Here most of us fail lamentably because we think we need to be mucho about things and also we have been brought up in such a way that we can’t appreciate, but we are creatures of acquired behavior and if we put our mind to it we will definitely manage to appreciate our better half

6. A Man of Encouragement (v. 28, 29)

The Proverbs 31 man tells his wife “You’re the best”, not for anything she’s done for him or for anything he wants from her. He encourages her, “praises her”, because of who she is.

Let us be this man to our families and you will see the miracles that will happen.

Happy wife happy life

Lessons from john the Baptist

Key text John 3:27
AMP “John answered, A man can receive nothing [he can claim nothing, he can take unto himself nothing] except as it has been granted to him from heaven [a man must be content to receive the gift which is given him from heaven, there is no other source]”
NIV “A person can receive only what is given them from heaven”

What is it that you have and have you realized that has ONLY come from heaven and that it is a gift?
Family, spouse, Job/employment/occupation/business, house, health, skills etc..Have you been thankful and thanked God for it?
John the Baptist was the one who had a special message from God to prepare the people for Christ’s first coming, to preach and ask for repentance among the believers (Jews), he was the first one to baptize.

As individuals and as a church how do we react when we are the only ones who have exclusive information or knowledge about something?
Are we humble or proud?
Do we use this position to oppress others?
As for John he preached mightily the gospel he had and was very stern in the warning, bordering on being harsh (calling Pharisees as a brood of vipers).
He was true to his calling are you?
John teaches us that the laborers can rest (die but the work continues).
God’s work is never dependent on one person, it is meant for a lot of people to share the work, so you must not feel bad when your time to stop work is up.

FICTION| The African Bull

“This girl, Margaret…when I met her she was cleaning toilets at a public library. She was at the edge of poverty. And now she has the audacity to even consider writing books about me? I am revolted!”

Thabo quickly realised that this rant required more than the sweet lubricant of an almost warm beer. He needed an audience. For the first time since he arrived, Thabo lifted his gaze from the beer before him and the empty bottles that stood abandoned beside it. He turned his head to search the bar for someone lucky enough to be an audience to his wisdom-building sorrow. What he found instead was a barroom filled with men whose eyes were glued to the screen before them. They were definitely far too interested in the English Premier League game to be torn away from it by even the frothiest promise of beer. Thabo turned his…

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